SYNTHESIS AND BIOLOGICAL EVALUATION OF THIAZOLE DERIVATIVES

Abstract

This study investigates the synthesis and biological evaluation of novel thiazole derivatives. A series of thiazole compounds were synthesized from thioamide and α-haloketone, characterized using NMR, IR, and MS. In vitro assays revealed significant cytotoxicity against cancer cell lines (HeLa, MCF-7, A549) with IC50 values between 8.5 and 20.0 µM, and notable antimicrobial activity with MIC values ranging from 2.0 to 6.5 µg/mL. In vivo studies demonstrated effective tumor reduction and improved infection outcomes in animal models. Structure-activity relationship analysis identified key structural features, such as -OH and -NH₂ substitutions, that enhance biological activity. These findings suggest that thiazole derivatives have potential as therapeutic agents for cancer and antimicrobial treatments. Future research should focus on optimizing these compounds and evaluating their long-term safety and efficacy in clinical settings.